6 kda) regulatory protein found in most tissues of eukaryotic organisms, i. It was discovered in 1975 by gideon goldstein and further characterized throughout the late 1970s and 1980s. Four genes in the human genome code for ubiquitin ubb, ubc, uba52 and rps27a.
Ubiquitin had been isolated from thymus prior to its identification as apf-1. 10 the evidence available at the time indicated that it was a universal constituent of living cells. Indeed, ubiquitin is present in all eukaryotic cells and is one of the highly evolutionarily conserved proteins.
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